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10.1210/clinem/dgaf401 J Clin Endocrinol Metab

That dual action is the headline difference: by engaging a second receptor, tirzepatide tends to produce a stronger effect on appetite and metabolism

Proglucagon signalling in the rat Dorsomedial Hypothalamus: physiology and high-fat dietmediated alterations

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It is thought that skeletal muscles (such as those in the pelvic floor) can adapt to metabolic needs (such as insulin needs) in order to maintain energy balance and nutrient use, therefore decreasing activation of those muscles for energy conservation

Individuals who are pregnant or breastfeeding, have a history of certain thyroid conditions or pancreatitis, are generally not suitable