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To fully realize GLP-1's promise to transform healthcare for a wide range of chronic diseases, we need to optimize GLP-1RA design for individual diseases, create individualized treatment plans, and learn more about their mechanisms and long-term consequences

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The current boxed warning for thyroid C-cell tumors based on rodent data, and warnings for acute pancreatitis, gallbladder disease, acute kidney injury related to volume depletion, severe gastrointestinal reactions, diabetic retinopathy complications in patients with type 2 diabetes, and other concerns

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At baseline, the mean eGFR was 82 mL/min/1.73 m2 and 35% of patients had eGFR 90 mL/min/1.73 m2

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Liver Strain GLP-1s are metabolized by your liver

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