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Those who have successfully implemented sustainable changesincluding regular physical activity (UK Chief Medical Officers recommend at least 150 minutes of moderate-intensity activity weekly), improved dietary patterns, and behavioural strategies for weight managementmay have better outcomes if discontinuing GLP-1 therapy

Instead, the medication offers a gentle but sustained reduction in appetite, which can lead to more consistent and manageable weight loss over time

Most research has focused on dietary patterns and individual nutrients, with findings generally showing modest effects on GLP-1 levels and metabolic outcomes

Semaglutide works by mimicking a natural hormone that helps control appetite and digestion

Reviewed on Jan 02, 2026

Patients with obesity are more likely to discontinue GLP-1 therapy than those with diabetes, citing lower perceived necessity, stigma, and limited coverage as key drivers 7