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Retatrutide adds glucagon receptor agonism to the GLP-1 and GIP targets already covered by tirzepatide, which is hypothesised to further stimulate hepatic fatty acid oxidation and lipid clearance

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With respect to the previously mentioned study, this proof-of concept study has important methodological strengths residing in the availability of baseline and post-treatment hepatic biopsies

As a potent triple agonist, Reta also helps scientists examine glucose regulation, metabolic signaling, and energy balance under tightly monitored experimental conditions

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