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Description
Dopamine neurons of the VTA target the NAc, as evidenced by the appearance of fluorescently labeled Ex4 (Fluro-Ex4) in the NAc following systemic administration (Hernandez et al., 2019)

Hence, it increases the demand for GLP-1 drugs for their effective management

In mice, 7-day treatment with liraglutide prior to induction of myocardial infarction increases survival and reduces cardiac injury and infarction size, while improving cardiac output [614]

18 Connectivity Map (CMap) is a crucial tool for drug repurposing by screening compounds that can generate gene expression profiles similar to that of the target drug

Sure enough, exendin-4 displayed all the same effects as GLP-1, triggering insulin secretion from the pancreas and slowing digestion

Fortunately, no tachyphylaxis was observed
