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Some drugs maintain their Phase 2 signal into Phase 3

3.6 Endocrine effects The combination of GLP-1 receptor agonists and metformin has not been associated with an increase in the rate or severity of clinically relevant hypoglycemic events [32, 34, 45, 46, 115-122]

Sources 1 Clinical Trials Arena, 2024 was a record year for obesity trials and 2025 is already poised to take over

(null) [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Hardie D.G., Ross F.A., Hawley S.A

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Until such studies confirm these therapeutic options efficacy, patients should consult healthcare providers before considering GLP-1 agonists as complementary approaches to conventional treatments