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Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat

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Multivariate analysis of fasting glucose showed that fasting glucose was lower in the placebo arm at 12 months (2.2 mmol/L 95%CI: 0.4, 4.1, p = 0.027) but not at 6 months (1.4 mmol/L, 95%CI 1.1, 3.9, p = 0.24) (Supplementary Tables 10.1 and 10.2)

A lower EC 50 indicates a higher peptide potency, or ability to agonise receptor signalling

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In the Phase 3 trials, nausea was reported by approximately 44% of patients on Wegovy (semaglutide 2.4 mg) and approximately 28% of patients on Zepbound (tirzepatide 15 mg) during dose titration, usually mild to moderate and usually improving with time and dose stabilization