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It is possible that expression of the T149M variant and/or decreased baseline circulating GLP-1 levels in human cocaine addicts may serve as predictors of treatment response and/or relapse, as these phenotypes are associated with decreased endogenous GLP-1 signaling in the body

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Conversely, people who view the switch as an active choice to optimize their protocol often maintain better psychological adjustment and persistence through temporary difficulties

This pattern may repeat with subsequent dose increases to 1 mg or 2 mg