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Questions to Ask Your Doctor When you see a doctor, you may want to ask: What kind of weight loss can I expect to achieve

PMID: 36462999 Contreras C et al (2017): Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway
The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo

A small trial of 28 women with PCOS showed that just eight weeks of high intensity interval training lowered their weight, waist-to-hip ratio, cholesterol levels, and insulin resistance

Many people remain on starter doses that are intended only for tolerability, not therapeutic effect

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