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Collins FW et al

Patients with personal or family history of medullary thyroid carcinoma should not use these drugs

Executive Compensation Chapter 6: Forces of Change for Drug Distribution 6.1

According to a consensus statement developed by international experts, diagnosis should involve screening for both obesity and sarcopenia followed by assessment of muscle mass, strength and function, and altered body composition

Common contributors include sleep disorders, chronic stress, hormonal imbalances (particularly thyroid dysfunction), nutritional deficiencies (such as vitamin B12 or iron), autoimmune conditions (like multiple sclerosis or lupus), medications, and metabolic disorders including diabetes

Issues like nausea, diarrhea and Ozempic face (the gaunt look you get from rapid weight loss) are well-known and even expected
