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To overcome these barriers, peptides ideally need to have a large therapeutic index, some stability in the GI tract, a long elimination half-life, and a relatively low clearance rate [3, 43]

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4.4 Effects on nonalcoholic fatty liver disease Tirzepatide targets multiple pathways related to NAFLD and nonalcoholic steatohepatitis (NASH), including hepatic fat accumulation, inflammation, and liver fibrosis (Heyens et al

doi: 10.1136/bmj-2023-076410, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Shaefer CF, Kushner P, Aguilar R