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Some users report feeling intoxicated more quickly than before starting therapy

Breanna Hansen, Internal Medicine Resident, Cedars Sinai TWEET PREPARATION: Dr

Since the Food and Drug Administration (FDA) approved glucagon-like peptide-1 receptor agonists (GLP-1RAs), including liraglutide, semaglutide and tirzepatide, for weight loss treatment, GLP-1RAs suppress appetite by activating the GLP-1 receptor (GLP-1R) signalling pathway in the central nervous system and stimulate metabolic activities in the gastrointestinal tract, pancreas and liver, thereby promoting insulin secretion, reducing glucagon secretion, delaying gastric emptying and inhibiting gastrointestinal motility

High levels of GLP-1R activation are known to be associated with dose-limiting gastrointestinal side effects, such as nausea and vomiting