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Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 after single subcutaneous administration in healthy subjects

There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis

Exenatide (EC 50 = 0.60 nM, E max = 125%) and liraglutide (EC 50 = 1.8 nM, E max = 117%) were 380- and 130-fold more potent, respectively, and caused somewhat greater receptor internalization relative to PF-06882961 (Table S5)

Liraglutide's approval for weight management indicated a shift towards using GLP-1 agonists explicitly for this purpose, highlighting their dual benefits in controlling blood sugar and reducing weight