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Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin

[DOI] [PubMed] [Google Scholar] 28.Spiegelman B.M

In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks

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Supplementary Information Additional file 1 (download DOCX : Figure S1

The FDA has approved these medications for two primary uses : managing type 2 diabetes and aiding in chronic weight management for individuals with obesity or those who are overweight and have related health conditions
