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### Competing Interest Statement ASK, AMM, MCG, JMD, CB, CL, SWB, DJL, PML, DRD, JMC, JPF, YL, ARS, DAT, DWP, SH, RBR, MSL, and DAG are employees and stockholders of Pfizer Inc

Understanding the difference between appetite-suppressing drug classes helps patients and providers choose the most appropriate treatment based on individual physiology, comorbidities, and clinical response patterns

June 2, 2026 Results of an American College of Radiology-managed retrospective study involving 110,000 womenpresented at the 2026 ASCO Annual Meeting, shows that those who took GLP-1 medications were up to 35% less likely to develop breast cancer than those who did not take GLP-1 drugs. ACR urges funding of a large prospective study to clarify impact of these drugs on cancer incidence and prevention.

Methods In 10,310 participants from the Atherosclerosis Risk in Communities (ARIC) Study (aged 4670 years, ~55% women, ~20% Black adults) without diabetes at baseline (19901992), we used Cox regression to characterise age- and sex-adjusted associations of prediabetes with ~30 year incidence of complications (composite and separately), including atherosclerotic CVD (ASCVD), heart failure, chronic kidney disease (CKD) and all-cause mortality before and after accounting for intervening incidence of diabetes, modelled as a time-varying variable

Its not clear why Tirzepatide isnt being tested for the same diseases (it could be a commercial decision rather than a medical one)