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A recent market survey (see Table 1) estimated that only 34% of first-time Wegovy prior authorizations under CVS were approved ( [46] ) ( [4] ) (implying a 66% denial rate on initial submission)

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While improved metabolic health and weight loss might theoretically reduce fatigue burden, semaglutide's gastrointestinal effects and associated dehydration could potentially worsen fatigue in some individuals