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Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

Once the leader in GLP-1 medications, Novo Nordisk has lost ground to Eli Lilly, which now captures more new prescriptions for obesity medications

(Table 1)

Because they slow digestion, GLP-1 drugs may interact with some medications and make them not work as well

10.1089/152091501750220037 60 WhithamM.FebbraioM

Inclusion of GLP-1 agonists regardless of history of obesity reduced HRs and narrowed CIs but did not change the significance of the results (Table 2)