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In rodents, human enteroendocrine cells, and in perfused porcine ileum, cholinergic agonists, which bind to receptors in both the enteric and parasympathetic nervous system (PNS), stimulate GLP-1 secretion (4, 14, 84, 192)

GLP-1 has revolutionized diabetes and obesity treatment, while GLP-2 offers hope for those with serious intestinal disorders

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Target 64 to 80 ounces of water per day minimum, and more if you are active or experiencing digestive side effects

This situation underscores the need for further research to characterize global pediatric usage as well as the nuances of prescribing these medications across clinical contexts

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