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Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice

Hunger dropped significantly and the scale started moving again

J Biol Chem 259(3):183441 Xie S, Zhang M, Shi W, Xing Y, Huang Y, Fang WX, Liu SQ, Chen MY, Zhang T, Chen S, Zeng X, Wang S, Deng W, Tang Q (2022) Long-term activation of glucagon-like peptide-1 receptor by dulaglutide prevents diabetic heart failure and metabolic remodeling in type 2 diabetes

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Patients taking the 15 mg dose lost an average of roughly 21% of their body weight over 72 weeks
There was no improvement in glucose tolerance in late gestation in the mice that had received pre-pregnancy liraglutide compared with obese mice that had no GLP1RA intervention
