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Furthermore, GLP-1RA is related to decreased body weight, which is unfavorable for bone fractures as weight loss induces mechanical loading and bone mass decrease

At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects ( Several studies reported that inappropriate ANGII/AT1R activation occurs because of different mechanisms, particularly in patients with T2DM

Takeaway for pharma strategy folks: This is a classic case where demand visibility is strong (12-24 months+), but execution timelines and compliance readiness will separate the winners

J Appl Physiol (1985) 122(3):549558 [DOI] [PubMed] [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article