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--- The net cost per patient fell from ~$12,000 annually in 2021 to ~$6,830 in 2025, but utilization grew faster than prices fell

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A comprehensive literature search was conducted across the PubMed, Embase, and Google Scholar databases for peer-reviewed articles published from inception through June 15, 2026, focusing on the landmark SURPASS, SURMOUNT, and SUMMIT trial programs, relevant cardiorenal post hoc analyses, emerging body recomposition trials, and real-world cohort-switching protocols

Semaglutide users often experience rapid initial weight loss, but understanding the difference between fat loss and fluid loss helps set realistic expectations and maintain healthy hydration during treatment