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doi: 10.3390/ijms21041509 [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Rao Kondapally Seshasai S, Kaptoge S, Thompson A, et al

The Aryl hydrocarbon receptor ( AHR ) is a protein found in the human body that plays a crucial role in various physiological processes

It can also be prescribed for those who are overweight, with a BMI of 27 or higher, if they also have at least one weight-related health condition

A 2021 study published in Lancet Diabetes & Endocrinology examined body composition changes with semaglutide and found that approximately 70% of weight lost was fat mass, with notable reductions in visceral adipose tissue volume

For now, we should continue to follow the Black Box Warning: those individuals with a family or personal history of MTC or MEN2 should avoid GLP-1 RAs until we have a greater understanding of what is happening in the human thyroid c-cells

In 2014, Saxenda became the first GLP-1 analog approved for weight loss, and in 2021, semaglutide (Wegovy), became the second GLP-1 analog to receive this indication