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Survodutide (BI 456906) was evaluated in two phase I studies involving healthy volunteers and individuals with overweight/obesity

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The primary limitation relates to the modest sample size and short intervention duration, which may limit precision and long-term inference but does not substantially undermine internal validity under JBI criteria

The EDE-Q is a 28-item questionnaire adapted from the clinician-based interview Eating Disorder Examination, designed to assess the range and severity of disordered eating using four subscales (Restraint, Eating Concern, Shape Concern and Weight Concern) and a global score [26]

It's also worth noting that many initial studies focused on individuals without pre-existing major depression

But their introduction, in addition to the expanding number of indications for which they are used will increase demand, and thereby help drive down cost as more companies enter the market (Mallapaty)