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Some individual product SmPCs list musculoskeletal symptoms as uncommon adverse reactions, so frequency varies by specific medication

All authors had access to the study data, critically reviewed the manuscript and approved the final version to be published

This has also been addressed in our rewrite of some of the sections on dimer-based therapeutics, where we mention several poly-drug approaches

Why this matters: The findings suggest that GLP-1-based medications may play a meaningful role in managing heart failure in people with obesity, though the smaller trial size means further research is needed to confirm these results

This side effect relates to rapid weight loss (telogen effluvium) rather than the medication itself and can occur with any significant weight loss from any cause