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In contrast, hyperandrogenic phenotypes have been associated with altered adiposity, neuroendocrine activity, and nociceptive processing (Dumesic et al., 2016
The most frequently reported effects have been gastrointestinal, including nausea, diarrhoea, constipation and vomiting
doi: 10.1055/s-0042-101794 82 BakbakETerenziDCTracJZTeohHQuanAGlazerSAet al
Gradual dose increases (under medical supervision) can restore appetite suppression and metabolic benefits
Dimitriadis, Kings College Hospital NHS Foundation Trust, United Kingdom
Kidney function matters because semaglutide is cleared partly through renal pathways, and patients with significantly reduced kidney function may require closer monitoring or dose adjustments
