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Mounjaros advantage comes from its dual mechanism of action : Ozempic activates only GLP-1 receptors Mounjaro activates both GLP-1 and GIP receptors GIP (glucose-dependent insulinotropic polypeptide) enhances the bodys natural insulin response and may have independent effects on fat metabolism and appetite suppression

Subsequent studies have confirmed reductions in visceral adipose tissue (VAT), the metabolically active fat surrounding internal organs that contributes to cardiometabolic risk

Recent studies are reporting, however, that 30% of patients discontinue GLP-1 drugs in the first month with significant muscle mass loss

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Interestingly, a recent study has shown that 14 days of cocaine self-administration in rats was associated with increased ghrelin and GLP-1 plasma levels while leptin and insulin levels were decreased [143]