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When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)

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More serious but less common risks include pancreatitis, gallbladder problems, kidney issues and, based on animal studies, a theoretical risk of thyroid C-cell tumours

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