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They also slow down the digestive process, which leads to appetite suppression and weight loss

In contrast, long-acting agonists (such as albiglutide or dulaglutide, or extended-release exenetide) have a stronger effect to reduce fasting glucose levels mediated by their effect on insulin and glucagon release

Place in Therapy There are a variety of stages of a patients weight-loss journey where semaglutide could be used, including first-line treatment, in combination with structured lifestyle changes

Tirzepatide vs Semaglutide vs Retatrutide Three incretin-class compounds dominate the conversation: tirzepatide (dual GIP/GLP-1), semaglutide (GLP-1 only, sold as Ozempic and Wegovy), and retatrutide (triple agonist GLP-1 + GIP + glucagon, still investigational)

Follow the instructions from your prescriber carefully and stay in touch to help make the transition smooth and successful

combining is safe but unnecessary if semaglutide is already producing the desired effect