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In a 2024 review of three peptides, the FDA noted side effects like increased heart rate, chest tightening, headache, nausea, diarrhea, and elevated liver enzymes, as well as skin irritation and pain at the injection site

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Bea S., Son H., Bae J.H., Cho S.W., Shin J.-Y., Cho Y.M

Perkovic, V., et al

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While semaglutide is effective and safe in managing type 2 diabetes and supporting weight loss, regular monitoring is key to ensuring it remains beneficial for your health over time

Significant levels of liraglutide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, indicating that liraglutide could cross the BBB (125)