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Scientifically, they work by mimicking a natural hormone in your body called glucagon-like peptide-1, which is released in the gut after you eat

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A failure can be defined as weight regain (WR) after successful initial weight loss or insufficient weight loss (IWL)

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For example, one of the first GLP-1 drugs that entered the U.S

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Johnson D.G., Goebel C.U., Hruby V.J., Bregman M.D., Trivedi D