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Patients treated with tirzepatide lost an average of 21.1% of their body weight since randomization (co-primary endpoint), compared to an average weight gain of 3.3% over 72 weeks for patients treated with placebo, for a placebo-adjusted net weight change of -24.5%

For example, it has been reported that ERR -null mice have reduced fat mass and are resistant to DIO (Luo et al., 2003)

"Ozempic Face" - an increase in signs of aging in the face caused by weight loss that reduces subcutaneous fat

This milestone is more than just the introduction of a new product

Of note, over the last years, an array of unimolecular GLP1-based poly-agonists, with different mechanisms of action, have been developed and experimentally validated for the treatment of metabolic syndrome, holding superior efficacy relative to conventional GLP1-RA 33,34,35

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