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What about ANY of the cardiometabolic data for the 104 week extension arm, especially the 4mg max tolerated dose and the placebo arm MTD

The magnitude of this shortened transit time from TN controls was significantly greater in cold-stressed GLPDRKO mice (Fig
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Having controlled glucose levels can help prevent severe complications from type 2 diabetes like kidney disease, retinal diseases, neuropathy (losing feeling in the hands and feet), and development of non-healing wounds in the feet, and experts are now looking into whether GLP-1s reduce the risk for those complications

GLP-1RAs may improve MASLD by modulating the gut-liver axis, with enhanced effects through dietary interventions and microbiome-targeted therapies involving SCFAs and GLP-1 pathways
Resolving the paradox Several hypotheses attempt to explain why the same medication class can both cause and relieve pain: Dose-dependent effects
