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Therefore, it was further inferred that exendin-4 might first bind to GLP-1R and act on the PKA pathway, which in turn affects the Wnt/-catenin pathway in the osteoblasts, reduces the expression of sclerostin, and promotes the formation of bone (Kim et al., 2013)

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Patients may need to begin a clear liquid diet or modified prep protocol 48 to 72 hours in advance, rather than the usual 24-hour prep window