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By contrast, linagliptin and alogliptin bind within the enzyme's catalytically active pocket through interactions with both the S 1 /S 2 and S 1 '/S 2 ' binding sites, which are formed by a combination of aromatic amino acids, including Phe357, Tyr547, Tyr631, Tyr666, Trp629, and His740

The Journal of Clinical Investigation, 121, 24132421

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GLP-1 has inhibitory effects on pancreatic -cells, leading to a reduction in glucagon secretion [2-3]

doi: 10.1056/NEJMoa1903822 30 TamborlaneWVBishaiRGellerDShehadehNAl-AbdulrazzaqDVazquezEMet al