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The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties, says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial

1991 Jul;78(1):33-6
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More receptors activated does not automatically mean better for every person

A large number of patients on GLP-1 medications report that their mouth feels drier than usual, sometimes described as a "sandpaper" feeling, particularly at night
