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Due to the extensive amount of interest in these drugs, GLP-1 co-agonists are also being developed around the world to treat T2DM or obesity, and some show greater effects than Ozempic, Saxenda, or Wegovy [30,31]

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The most important and most frequently used indication for DPP-4 inhibitors is their add-on use in patients who are not sufficiently controlled on metformin monotherapy ( DPP-4 inhibitors can be administered in patients with impaired kidney function due to the good safety and tolerability

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