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And it also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum

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2 Also in development are GLP-1 conjugates that combine GLP-1 and GCG agonists (eg, survodutide), GLP-1 and GIP receptor antagonism (eg, MariTide), and GLP-1 RA-amylin receptor agonists (eg, amycretin, cagrilintide-semaglutide)

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Bridges HR, Jones AJ, Pollak MN, Hirst J (2014) Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
