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Administration of liraglutide to normal and diabetic mice before inducing MI reduced cardiac rupture and infarct size, improved cardiac output, and modulated the expression of cardioprotective genes in the mouse heart, including Akt, GSK-3beta, PPARbeta-delta, NRF-2, and HO-1

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As NAD+ levels naturally decline with age, supplements designed to raise these levels typically through precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) have grown in popularity