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[DOI] [PubMed] [Google Scholar] 3.Speakman J.R., Levitsky D.A., Allison D.B., Bray M.S., de Castro J.M., Clegg D.J., Clapham J.C., Dulloo A.G., Gruer L., Haw S., et al

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(1994) with the possible exception of Phe- 12 (substitution to Ala resulted in 133-fold reduced affinity and 13-fold reduced potency), although the larger Tyr side chain in the Xenopus sequence is likely to be a more acceptable substitution compared with Ala