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The modified treatmentregimen estimand will be evaluated in the full analysis set (FAS), which is based on the mITT for efficacy analyses population regardless of adherence to study treatment and regardless of initiation of other OMMs, GLP1 receptor agonists, GIP/GLP1 receptor agonists, or DPP4 inhibitors

Rather than a fixed target, aim for pale yellow urine as an indicator of good hydration

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For the change in body weight, seven trials were at high risk of bias and one trial had some concerns

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For the dataset of the non-acylated tirzepatideGIPRmini-G s Nb35 complex, automated particle selection yielded 7,204,521 particles, which were subjected to reference-free 2D classification, producing 2,718,249 particles with well-defined averages