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Most incretin-based compounds target only the first two the addition of glucagon receptor agonism distinguishes this compound in research settings

These experiences are supported by research

References: Elective perioperative management of adults taking glucagonlike peptide1 receptor agonists, glucosedependent insulinotropic peptide agonists and sodiumglucose cotransporter2 inhibitors: A multidisciplinary consensus statement: A consensus statement from the Association of Anaesthetists, Association of British Clinical Diabetologists, British Obesity and Metabolic Surgery Society, Centre for Perioperative Care, Joint British Diabetes Societies for Inpatient Care, Royal College of Anaesthetists, Society for Obesity and Bariatric Anaesthesia and UK Clinical Pharmacy Association

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In this Review, we summarize the data from CVOTs of GLP1R agonists in patients with T2DM and describe the actions of GLP1R agonists on the heart and blood vessels