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R.ChengI.et al (2020)

PMID 19810843

Sodium-glucose co-transporter-2 inhibitors and atrial fibrillation in the cardiovascular and renal outcome trials

Groups of ten size-matched islets were incubated at 37 C in HEPES-buffered Krebs-Ringer bicarbonate buffer (HKRB) composed of (in mM) 4.7 KCl, 1.2 KH 2 PO 4 , 129 NaCl, 5 NaHCO 3 , 1.2 MgSO 4 , 1.8 CaCl 2 , and 10 HEPES, with pH adjusted at 7.4 using NaOH supplemented with 2.8 mM glucose, followed by test incubation for 1 h with 2.8 or 11.2 mM glucose in the absence or presence of d-allulose (20 mM) or d-mannitol (20 mM)

Is using a lower GLP-1 dose ever reasonable

Blood samples were obtained at baseline and during the fasting steady-state period (at 30, 20, 10 and 0 min during the last 30 min of the continuous tracer infusion) to assess plasma glucose and insulin concentrations, and isotopic enrichments of glucose and glycerol