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The GRADE assessment rated 24 outcomes (20%) as High, 17 (14%) as Moderate, 25 (21%) as Low, and 52 (44%) as Very Low

DNA damage signaling pathways and cellular senescence are triggered when telomeres are very short [16]

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In a statement published alongside the results, Amgen said: Weight loss had not plateaued by 52 weeks, indicating the potential for further weight reduction. It added that improvements were recorded across other cardiometabolic measures, including waist circumference, blood pressure, high-sensitivity C-reactive protein (hs-CRP) and select lipid parameters

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