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Industry analysts suggest that meaningful pricing changes in the GLP-1 market could make coverage economically viable again within three to five years

Regenerons Phase 2 COURAGE trial echoed these results in humans: combination therapy significantly reduced fat while preserving up to 81% of lean mass loss compared to semaglutide alone

Affordability remains the "major barrier" to widespread adoption, making reimbursement a key strategic aspect

doi: 10.1042/CS20110006

The fraction of weight lost as fat-free mass depends on baseline adiposity, age, sex, diet, protein intake, inactivity, resistance training, metabolic state, and the rate and duration of weight loss

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