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Insurance coverage may also be worse for tirzepatide depending on your plan

The best outcomes usually happen when tirzepatide is combined with healthy nutrition, regular activity, and professional medical guidance

Maintenance dosing for tirzepatide often settles at 5-10 mg for users who reached peak weight loss at higher doses, though the optimal maintenance dose is highly individual

Tirzepatide Reduces 24-Hour Ambulatory Blood Pressure in Adults With Body Mass Index 27 kg/m2: SURMOUNT-1 Ambulatory Blood Pressure Monitoring Substudy

The primary one is practical: if tirzepatide makes you nauseous, you can sleep through the worst of it

The side effects of tirzepatide are the same as the GLP-1 medications, primarily nausea and gastrointestinal disturbance