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To conclude, our data support further investigations of MEDI4166 as a potential treatment for T2D patients with high cardiovascular risk

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Glucagon-like Peptide-1 Receptor Agonist can slow the transit time of the gastrointestinal tract and may suppress appetite

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This is further supported by the near-complete absence of cardiac Glp1r mRNA in Glp1r Tie2/ mice (57), suggesting that mouse cardiac Glp1r expression is primarily contributed by endothelial cells and/or immune cells

Erreger et al