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Frequently asked questions Weve tried to answer some of the most common questions about semaglutide here

Am J Health Syst Pharm 62: 17381,2005

You should contact your GP or healthcare professional if you experience: Heavy bleeding (soaking through a pad or tampon every hour for several consecutive hours) or passing large clots Prolonged bleeding lasting more than seven days or bleeding that does not stop Severe pelvic or abdominal pain that is new, persistent, or worsening Postmenopausal bleeding (any vaginal bleeding occurring 12 months or more after your last period) this requires an urgent 2-week suspected cancer referral [11] Bleeding between periods that is recurrent, increasing in frequency, or accompanied by other concerning symptoms Signs of anaemia , such as extreme fatigue, dizziness, shortness of breath, or pale skin It is also important to seek advice if you have missed periods and there is any possibility of pregnancy

Semaglutide (Wegovy) and tirzepatide (Zepbound) have received FDA approval for chronic weight management in adults with a BMI 30, or 27 with at least one weight-related comorbidity, when used alongside diet and exercise

The 2.5mg dose is not therapeutic for weight loss

The factors favoring escalation to 12mg include: weight loss plateau before reaching goal, BMI above 40 with significant weight to lose, and good tolerability with minimal side effects during escalation