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Future studies in Professor Patti's laboratory could answer this question. The findings were featured in the paper, Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia, published in the Journal of Clinical Investigation

37 Wulffel, M.G., et al., Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial
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The amount in compounded tirzepatide (typically 0.5-1mg weekly) is well above the RDA but may not fully compensate for absorption issues and increased demands during rapid weight loss

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