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Research on this topic is still ongoing, however, and it may take time to determine the long-term effects of these drugs

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2 4 mg for weight management: a randomised, controlled, phase 1b trial

Even prior to the discovery of insulin, it had been proposed that hormonal factors produced in the intestine might have glucoregulatory actions 9

Some patients experience nausea, fatigue, or appetite changes in the first few weeks
If tirzepatide can reduce intracranial pressure enough to resolve headaches in IIH, it is plausible that it can reduce pressure enough to lower the migraine threshold in people without a formal IIH diagnosis
