changing from tirzepatide to retatrutide vs. Retatrutide: Key Differences Explained how to switch from semaglutide
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Alicia M

Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively
This finding has direct implications for how you should structure your calorie intake and macronutrient ratios

At Week 72, 250 (90%) late responders and 1267 (100%) early responders (by definition) had a body weight reduction of 5% or more (Figure 2A)

Its not a long-term solution, but it can prevent a gap in treatment
